RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CXCL10
RNA ID
RNA Type
mRNA
Alteration Pattern
histone modification
Species
homo sapiens
Detection Methods
qRT-PCR; ELISA; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
Year
2010
Function
Epigenetic dysregulation involving interactions between histone deacetylation and hypermethylation is responsible for targeted repression of IP-10 and potentially other antifibrotic genes in fibrotic lung disease and that this is amenable to therapeutic targeting.